In January 2024, Dr Khaled Alser founded a telemedicine initiative with a group of international physicians to support Palestinian surgical teams in managing gunshot and blast injuries during the genocide. He had co-written an academic paper about this initiative, which was published in the Lancet in August 2024, six months into his arrest.

He remained in the northern Gaza Strip until his martyrdom. He used to share some of his daily life on social media. He was known as the doctor who cut an umbilical cord with a knife and tied it with a wooden clothespin when a woman gave birth in their displacement site.