In 2008: The hematology and oncology department was transferred from Al-Nasr Hospital to the Rantisi Hospital, the neurology department was provided with EEG and EMG machines, and the cardiology department with an echocardiography machine. Additionally, the CT scanning department, the intensive care, reception, and the pediatric physiotherapy department became operational[17].

In 2009: A gastrointestinal endoscopy department was opened[6]. 

In 2010: a respiratory endoscopy department was opened[6].

In 2012: With funding from the Malaysian Al-Aqsa Al-Sharif Foundation, a gymnasium and a library were opened to serve the hospital's patients[18]. In addition, under the auspices of the Ministry of Health, a specialized nursery was opened[14].

In 2017: The pediatric hematology and oncology department was opened, funded by donors from Australia and implemented by the Oasis Foundation for Humanitarian Services[19].

In 2019: The hematology and oncology department was reopened after being renovated by Al-Wayam Charitable Society[12]. The Palestine Children’s Relief Society also announced the opening of the first pediatric cancer department in the Gaza Strip at the hospital[11]. In the beginning of 2016, the society started establishing the department with the aim of reducing medical referrals by 20%. The department includes 14 beds in the hospitals’ outpatient clinics, in addition to 16 equipped rooms[19][20].

In 2021: The Ministry of Health opened a mental health unit at the hospital and the Rahma Worldwide Foundation funded the renovation of the overnight department for gastroenterology, cardiology, and pulmonology patients[21].

In September 2015: The director of al-Shifa Hospital reported that power outages and lack of fuel led to the suspension of services at the Rantisi Hospital for 12 hours, endangering the lives of children in need of dialysis sessions[22].

In August 2018: Dr. Mohammed Abu Salmiya, director of the Rantisi Hospital, reported that many operations could not be carried out due to the lack of medicines. The hospital was also unable to provide the necessary treatment for colon, lung and lymphoma cancer patients due to the depletion of filgrastim stocks needed for patients to undergo chemotherapy. The hospital needed 1,000 injections of filgrastim every month, while the amount available over two months was 100 injections[23].

In September 2023: The hospital announced that it had run out of medical supplies and medicines for dialysis sessions[24].