The hospital stated that there were no medicines for cancer patients, that more than 2,200 requests for transfers abroad had been submitted, and the hospital administration re-launched an appeal to facilitate travel for the treatment of more than 2,600 cases in need of immediate treatment.

The Ministry of Health announced the death of four cancer patients as a result of the hospital being out of service due to targeting and running out of fuel.

Occupation forces bombed the vicinity of Al-Karama Specialized Hospital, rendering the hospital out of service as buildings adjacent to the hospital fell on it.

As the hospital entered its seventh day of Israeli siege and fifth day without communications, the PRCS announced that the hospital was completely out of service due to lack of available fuel and power outages. Staff continued to provide the best service they could to the injured as the hospital lacked power, food, medical equipment, food, and water. Staff were forced to use traditional medical methods due to the lack of supplies. Displaced people were forced to evacuate to the south on a specific route drawn by the Israeli military.

Occupation forces bombed the hospital.

On November 11,2024,occupation forces tightened the siege of the hospital by advancing towards the hospital's entrance, intensify the airstrikes around the hospital and PRCS headquarters, and fired live ammunition at the intensive care unit and displaced people sheltering in the hospital, causing several injuries. Occupation forces also opened fire at the clinics and at everyone moving outside of the hospital, killing a displaced person.

Occupation forces bombed a PRCS ambulance, injuring a paramedic and the driver. The director of Al-Quds Hospital told Human Rights Watch that the Israeli military did not provide prior warning. 

Occupation forces continued bombing the area around the hospital, injuring 9 people inside the hospital, destroying the intensive care units on the third and fourth floors of the hospital, damaging five ambulances and putting them out of service, and destroying a residential building in the northwestern area of the hospital.

Occupation forces stationed on the southern side of the hospital targeted it with indiscriminate gunfire, with bullets penetrating the walls of the sixth floor and damaging the central air-conditioning units. Two displaced persons, a young man and a child, were injured in the chest and abdomen in the indiscriminate Israeli shooting.

Occupation forces maintained their threat to bomb the hospital and demand to evacuate the hospital and the Palestinian Red Crescent headquarters. The hospital continued to operate despite the nearby bombardment.

Occupation forces bombed the vicinity of the hospital, destroying several buildings near the hospital. The military also tell people in the area to evacuate.

Until the end of November, Israeli threats to evacuate the hospital continued along with intensive airstrikes targeting the surrounding area.

Damage to the hospital facilities includes: